Carboxyhemoglobin (SpCO®)

Carbon Monoxide

Carbon Monoxide

  • Carbon monoxide (CO), a colorless and odorless gas, is a byproduct of the incomplete combustion of any carbon-containing material.1
  • Sources of CO include inadequate ventilation of heating sources, automobile exhaust, faulty furnaces, exposure to methylene chloride (an industrial solvent often used for cleaning and as paint thinner), as well as cigarette smoke and smoke from fires.2
  • Exposure to CO raises levels of circulating carboxyhemoglobin (COHb) in the blood.

Measuring Carbon Monoxide with SpCO

Measuring Carbon Monoxide with SpCO

  • Pulse CO-oximetry is a continuous and noninvasive method of measuring the levels of various blood constituents, including carbon monoxide (SpCO).
  • Measurements are taken by placing a sensor on a patient, usually on the fingertip for adults.
  • Accuracy Range: 1-40% with 3% ARMS.3
Masimo - SpCO - rainbow SET Technology Platform

rainbow SET™ Technology Platform


Masimo rainbow SET is a noninvasive monitoring platform featuring Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry with the option to measure multiple additional parameters.

  • Oxygen Saturation (SpO2)
  • Pulse Rate (PR)
  • Perfusion Index (Pi)
  • Pleth Variability Index (PVi®)
  • Oxygen Content (SpOC™)
  • Total Hemoglobin (SpHb®)
  • Methemoglobin (SpMet)
  • Carboxyhemoglobin (SpCO®)
  • Acoustic Respiration Rate (RRa®)


  1. 1.

    McEvoy, M. Sneak Attack: What makes carbon monoxide so insidious? The Silent Killer. J Emerg Med Svcs. October 2010: 4-9.

  2. 2.

    Weaver, LK. Carbon Monoxide Poisoning. N Engl J Med. 2009; 360(12): 1217-25.

  3. 3.

    ARMS accuracy is a statistical calculation of the difference between device measurements and reference measurements. Approximately two-thirds of the device measurements fell within +/- ARMS of the reference measurements in a controlled study.


Masimo - Thumbnail of SpCO Studies

Follow the link for available SpCO studies.

Masimo - Thumbnail of Noninvasive and Continuous SpCO

Follow the link to receive more information about Noninvasive and Continuous SpCO.

Masimo devices with SpCO monitoring are not intended to be used as the sole basis for making diagnosis or treatment decisions related to suspected carbon monoxide poisoning; they are intended to be used in conjunction with additional methods of assessing clinical signs and symptoms.

Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. See instructions for use for full prescribing information, including indications, contraindications, warnings, and precautions.